August 23rd, 2023 Immunological Matching in Sperm Donor Selection: Optimizing Compatibility In the exciting journey towards motherhood, where every detail is crucial to achieve a healthy and successful pregnancy, emerges a factor that often goes unnoticed: the immunological matching in the selection of sperm donor. In this article, we will delve into this fundamental aspect and explore how immunological matching, specifically through the KIR AA genotype, can make a difference in the compatibility between the receiving patient and the donor, exponentially increasing the chances of successful implantation and a pregnancy filled with joy and hope. 1. KIR AA Genotype and its Impact on Sperm Donor Selection KIR genes (inhibitory killer cell receptors) are an integral part of the body’s immune response. While the immune system is a natural wonder that protects the body from invaders, in the context of reproduction, this same protection can be counterproductive. The presence of the KIR AA genotype in the receiving patient can indicate a more active immune system in terms of Natural Killer (NK) cells. This increased activity can lead to a more intense immune response that, in certain cases, complicates the acceptance and optimal development of the embryo in the uterus. 2. GRAVIDA Strategy: Towards Immunological Compatibility At GRAVIDA, our mission is to provide the most exceptional and personalized care possible. When we encounter a patient with the KIR AA genotype, we take measures to identify a donor who possesses a compatible NK cell profile. This meticulous selection is based on the fundamental idea of improving immunological compatibility between the patient and the embryo, laying the groundwork for a more successful implantation process. 3. How Immunological Matching Increases the Chances of Successful Implantation Immunological matching through the KIR AA genotype has a profound impact on the chances of successful implantation. By opting for a donor with a compatible NK cell profile, we significantly reduce the likelihood of an adverse immune reaction. This meticulous and strategic process amplifies the opportunities for the embryo to be accepted and develop healthily in the uterine environment. 4. Immunological Matching at GRAVIDA: Essential Pillar for Fulfilling Pregnancy In summary, immunological matching based on the KIR AA genotype stands as a fundamental pillar in the selection of sperm donor at GRAVIDA. Our unwavering commitment to excellence drives us to consider every facet of compatibility, including the immunological aspect. By presenting patients with the option to choose a donor with a compatible NK cell profile, we are paving the way for a healthy pregnancy, empowering families to grow and thrive. 5. GRAVIDA’s Dedication to Personalized Care and Empowerment of Families At GRAVIDA, we know that each patient is a unique individual and that their journey to motherhood is equally singular. Our dedication to personalized care and our unwavering attention to detail create a distinct experience. If you are considering the possibility of assisted reproduction, we invite you to explore the power of immunological matching and how it can positively influence your journey to parenthood or motherhood. At GRAVIDA, we are here to accompany you every step of the way, working together to turn your dreams into a bright and exciting reality. Dra. Carmen Márquez Guevara Laboratory Director Comparte: